BCL2 and prostate carcinoma: The AKT pathway can be activated by various growth factors and plays a crucial role in promoting cell growth and blocking apoptosis in various cancer models, including prostate cancer, and it has already been reported that activated AKT phosphorylates several apoptosis-regulating proteins including BAD, a member of the pro-apoptotic BH3-only Bcl-2 family in prostate cancer cells [54,55].