HKII nuclear localization was increased twofold (from 20% to 40%; Figure 4A; ** p < 0.01) in A2780cp cells infected with an adenoviral construct (Adv) of wild-type p53 (multiplicity of infection (MOI) = 1.0; 12 h) and treated with CDDP (10 μM; 24 h) compared with Adv–LacZ as control (CTL) alone. This evidence concerns the gene HK2 and infection.