When comparing the nuclear HKII-P-p53 (Ser15) interaction in post-chemotherapy relative to pre-chemotherapy sections, we observed a notable increase in nuclear HKII-P-p53 (Ser15) interaction in a chemosensitive cancer (PFI = 40 m) associated with longer PFI, but not in a chemoresistant cancer associated with shorter PFI (PFI = 1 m) (Figure 1C). Here, HK2 is linked to cancer.