For example, KMT2D (MLL4) (42–52%), KMT2C (MLL3) (32–37%), KMT2A (MLL1) (19–30%), SETD1A (10–20%), NSD1 (17–19%), DNMT1 (12–17%), and SETD2 (11–15%) are among the most highly mutated genes in cSCC. The gene discussed is SETD2; the disease is skin squamous cell carcinoma.