In support of KMT2D’s role as a tumor suppressor in cSCC, inhibition of the histone demethylase enzyme that opposes KMT2D’s function, LSD1 (KDM1A), has been shown to both promote epidermal differentiation and suppress cSCC in 3D human cSCC organoids [74] (Figure 2). The gene discussed is KDM1A; the disease is neoplasm.