EGFR and glioblastoma: A phase I study of EGFRvIII-targeted CAR T cells, previously tested in orthotopic xenograft models of EGFRvIII+ glioma for efficacy and specificity to EGFRvIII over EGFR [111,112], was conducted in 10 patients with EGFRvIII+ recurrent GBM to evaluate safety and feasibility as the primary endpoints [87].