Non-small cell lung carcinoma (NSCLC) can transdifferentiate into small cell lung carcinoma (SCLC) during the acquisition of resistance to tyrosine kinase inhibitors against epidermal growth factor receptors (EGFRs); albeit, such transdifferentiation has also been noted among patients not exposed to such inhibitors [36]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.