One of the mechanisms by which circPRKDC (hsa_circ_0136666) might stimulate CRC progression is via the miR-136/SH2B1 axis, since the adapter protein SH2B1 (Src homology 2 (SH2) and pleckstrin homology (PH) domain-containing protein) acts as an oncogene in different tumors [124]. Here, SH2B1 is linked to colorectal carcinoma.