In CRC, circRNAs are implicated in activation of EMT and metastasis via changing the expression of transcription factors as ZEB1 (zinc finger E-box binding homeobox 1) or Snail (SNAI1) and Slug (SNAI2), via interaction with matrix mettalopeptidases (MMP2 or MMP14), via regulation of signaling pathways in CRC—Wnt/β-catenin, Hippo/Yap, JAK2/STAT3, and NF-κB signaling pathways. Here, JAK2 is linked to colorectal carcinoma.