In this study, authors claim that high expression of circPRKDC increases β-catenin and c-Myc levels, leading to activation of Wnt/βcatenin pathway in 5-FU resistant CRC cells via miR-375 deletion or FOXM1 (Forkhead box protein M1) overexpression [214]. This evidence concerns the gene FOXM1 and colorectal carcinoma.