Hsa_circ_0071589 is the next circRNAs with a complex mechanism involving the inhibition of the expression of another miR-526b-3p together with miR-600 [121,213] Hsa_circ_0071589 might regulate cisplatin resistance in CRC targeting oncogene KLF12 (Krüppel-like factor 12) by miR-526b-3p [213]. The gene discussed is KLF12; the disease is colorectal carcinoma.