We identified eight tumor suppressor miRNAs (miR-183-5p, miR-200c, miR-218, miR-372, miR-499a, miR-543, miR-589-5p, and miR-1827) that target regulators of the cytoskeleton (Ezrin, Tubulin Beta 3 Class III (TUBB3), moesin (MSN), Rho GTPase activating protein 19 (ARHGAP19), adducin 2 (ADD2), Ras Homolog Family Member C (RhoC), Vav Guanine Nucleotide Exchange Factor 3 (VAV3), Focal adhesion kinase (FAK), Thyroid Hormone Receptor Interactor 6 (TRIP6), Tubulin Polymerization Promoting Protein Family Member 3 (TPPP3)) and inhibits EC cell migration and invasiveness. The gene discussed is RHOC; the disease is neoplasm.