Tumor suppressor miRNAs that inhibit cell invasiveness and migration and were downregulated in EC (Table 2) were found to target regulators of EMT (5 targets, 12 miRNAs), growth factor signaling (14 targets, 18 miRNAs), cell cycle (9 targets, 10 miRNAs), cytoskeleton (10 targets, 10 miRNAs), hormone signaling (3 targets, 4 miRNAs), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling (3 targets, 5 miRNAs), epigenetic regulators (10 targets, 16 miRNAs). The gene discussed is AKT1; the disease is neoplasm.