SIX1 and neoplasm: Additionally, several tumor-suppressing miRNAs (miR-23a, miR-30c, miR-34c, miR-145, miR-194, miR-326, and miR-449a) target regulators of signaling (SIX Homeobox 1 (SIX1), Notch homolog 1 (Notch1), Interleukin 6 Receptor (IL-6R), SRY-Box Transcription Factor 11 (SOX11), SRY-Box Transcription Factor 3 (SOX3), G protein-coupled receptor 91 (GPR91), and N-Myc Downstream Regulated 1 (NDRG1)).