In the cytoplasmic fraction, they found an increase in HMGN2, PKM, GAPDH, CALR, HMGN, H3F3A, HMGN4, CLTA, ACLY, NUTF2, IDH2, TXNRD2, HIST1H4A, AIFM1, MDH2, CDC5L, as well as a decrease in FAM107B, HNRNPUL1, PLIN3, CBR1, PNP, AK1, MIF, CAPZA2, CES1, SOD2, CDC42, SPRYD4, RPS21, HPRT1 and WARS in CLL patients compared to healthy donors. The gene discussed is GAPDH; the disease is B-cell chronic lymphocytic leukemia.