HSPA4 and B-cell chronic lymphocytic leukemia: Eμ-TCL1 tumors (CLL) showed up-regulated ER stress response proteins and signaling components, including both subunits of the interleukin-5 (IL5) receptor, whereas Eμ-TCL1 plasma contained increased proteins of immune-response, inflammation and microenvironment interactions, with putative biomarker candidates for early-stage cancer (e.g., haptoglobin, nucleolin, 60S ribosomal protein L35, heat shock 70 kDa protein 4, 60S ribosomal protein L23a, inter alpha trypsin inhibitor heavy chain H1).