Additionally, the CLL International Prognostic Index (CLL-IPI) proposes a weighted grading of five parameters: (i) TP53 dysfunction, (ii) mutational status of IGHV, (iii) serum level of β2-microglobulin, (iv) clinical stage, and (v) age [3]. The gene discussed is HLA-G; the disease is B-cell chronic lymphocytic leukemia.