Finally, among the promising CLL therapies under investigation targeting several deregulated pathways are the cross-talk between CLL cells, the tumor microenvironment [42,43], the Wnt signaling pathway [44], various miRNAs [45], the Notch2 signaling pathway [46], the mitochondrial metabolism [16] and the epigenetic modifications [47]. Here, NOTCH2 is linked to neoplasm.