In CLL proteomics, a plethora of proteins involved in metabolism were found increased (e.g., GAPDH, GLUT2, NAXE, COX 6B, CPT2, GRPEL1, PKM, FABP3, IDH2, ACADM, ACAA2, CPT2), which could be considered as novel therapeutic targets alone or in combination with other targets. Here, IDH2 is linked to B-cell chronic lymphocytic leukemia.