Shull et al. carried out a RPPA study in 18 CLL patients and 6 healthy CD19+ B cell protein extracts, where they detected up-regulated AKT/mTOR-related proteins in CLL, i.e., eIF4G and phosphorylation at serine 65 of 4E-BP1 [99]. Here, MTOR is linked to B-cell chronic lymphocytic leukemia.