In the cytoplasmic fraction, they found an increase in HMGN2, PKM, GAPDH, CALR, HMGN, H3F3A, HMGN4, CLTA, ACLY, NUTF2, IDH2, TXNRD2, HIST1H4A, AIFM1, MDH2, CDC5L, as well as a decrease in FAM107B, HNRNPUL1, PLIN3, CBR1, PNP, AK1, MIF, CAPZA2, CES1, SOD2, CDC42, SPRYD4, RPS21, HPRT1 and WARS in CLL patients compared to healthy donors. This evidence concerns the gene PKM and B-cell chronic lymphocytic leukemia.