As a result, 91 proteins were significantly differentiated in the exosomes of CLL vs. healthy donors, including various vesicle markers (annexins, actin- and Ras-related proteins, 14-3-3 signaling proteins) elevated in CLL-derived exosomes, implying an altered composition of plasma exosomes in CLL. The gene discussed is YWHAQ; the disease is B-cell chronic lymphocytic leukemia.