Frezzato et al. performed an RPPA investigation in B lymphocytes from 57 CLL patients and 11 healthy individuals, identifying several proteins significantly altered in CLL vs. healthy B cells, highlighting, among others, a decrease in apoptosis-related proteins (cl-caspase-7, cl-caspase-9) and increased levels of HSP70 and Smac/DIABLO [100]. The gene discussed is CASP9; the disease is B-cell chronic lymphocytic leukemia.