The most interesting among them were programmed cell death protein 4 (PDCD4), UV excision repair protein (RAD23B) and lymphocyte-specific protein-1 (LPS1) that were down-regulated in UM-CLL cells after BCR activation, as well as heterogeneous nuclear ribonucleoprotein K (HNRNPK) that was up-regulated in UM-CLL. The gene discussed is RAD23B; the disease is B-cell chronic lymphocytic leukemia.