Specifically, they found decreased levels of prohibitin, PARP1, RhoA, Rac2, MYH9 and DHE3, as well as an increased abundance of TIF1B, ANP32A, HIST1H1C, SET, and of heat shock proteins, CH10 and CH60, in progressive CLL. The gene discussed is PHB1; the disease is B-cell chronic lymphocytic leukemia.