They suggested that RPS15 variants, which hold a prominent role in CLL pathobiology, may induce the up-regulation of RNA translation and peptide chain elongation, as well as a metabolic shift at the proteome level, in both HEK293T and MEC-1 cells (the down-regulation of pyruvate metabolism, TCA cycle, respiratory electron transport chain and metabolism of lipids and lipoproteins). Here, RPS15 is linked to B-cell chronic lymphocytic leukemia.