KLK3 and posterior cortical atrophy: Our data only provide the possibility to make some inference on the ability of PSA testing to exclude PCa in patients ≥ 65 years old with evidence of glandular inflammation: in this subgroup, a PSA value < 8.3 μg/L ruled out the presence of PCa of any grade with a negative predictive value (NPV) of 98.6% (CI: 90.8–99.8).