It is noteworthy that the predictive power of PSA testing in men > 62 years with a baseline PSA ≤ 4.0 μg/L changes slowly across subsequent rescreening rounds, being associated to an average OR of only 2.1 for advanced PCa, when the value increased of 1.0 μg/L [22]. Here, KLK3 is linked to posterior cortical atrophy.