PPM1D and acute myeloid leukemia: These mutations are also common in patients with MDS and AML, with the exception of PPM1D. Clonal hematopoiesis has also been detected by CNAs, overlapping with those karyotypic abnormalities seen in MDS and AML, such as trisomy 9, del(11q), del(13q), and del(20q) [71,72,73].