NLK is upregulated and correlated with poor prognosis in non–small-cell lung carcinoma and small-cell lung carcinoma, colorectal cancer, hepatocellular carcinoma, laryngeal cancer, osteosarcoma, and neuroblastoma (3, 4, 5, 6, 7, 8, 9, 10). This evidence concerns the gene NLK and neuroblastoma.