The NHE1 activity is upregulated in the settings of HF and T2DM (Packer 2017) that is contributed to intracellular Na+ and Ca2+ overload through coupling with the Na/K-ATPase, and NHE1 inhibition decreases cardiac remodeling, necrosis, and hypertrophy. The gene discussed is SLC9A1; the disease is type 2 diabetes mellitus.