A variant in MT1-MMP (rs1042704) significantly reduces its collagenolytic activity, and it is causatively associated with Dupuytren’s disease (Itoh et al., 2021), while variants, rs1003349 and rs1004030, in the promoter region of the MMP14 gene significantly increase its expression and are associated with an increased risk of gallbladder cancer in Indians (Vinay et al., 2021). Here, MMP14 is linked to gallbladder cancer.