p53 can directly bind to but repress the activity of the MMP14 promoter, thereby reducing MMP14 expression at the transcriptional level in HCT-116 (a human colon cancer cell line) and HT1080 cells (human fibrosarcoma) (Cathcart et al., 2016; Gramolelli et al., 2018). The gene discussed is MMP14; the disease is fibrosarcoma.