Similarly, the transcriptional factor PROX1 can bind to the promoter region of MMP14 and act as a transcriptional repressor to downregulate MMP14 expression in the lymphatic system and various cell lines such as HepG2 (hepatoma), SW620 (colorectal carcinoma), HuAR2T (endothelial cells), and MDA-MB-321 (breast cancer) (Gramolelli et al., 2018). Here, MMP14 is linked to breast cancer.