MMP14 and breast cancer: In human breast cancer cell line MDA-MB-231 and fibrosarcoma cell line HT-1080, Thr567 is phosphorylated by Src kinase upon activation of β1 integrin, which enhances endocytosis of MT1-MMP and results in redistribution of MT1-MMP to invadopodia and subsequent cell invasion (Grafinger et al., 2020).