Notably, while the circRNA of PKT2 has been reported to modify radiosensitivity in gastric cancer via the miR-369-3p/Zinc finger E-box Binding homeobox 1 (ZEB1) regulatory motif (11), circ-PRKDC regulates the miR-375/Forkhead box M1 (FOXM1) axis and the Wingless and Int1 (Wnt)/β-catenin pathway in colorectal cancer cells, thus contributing to chemotherapy drug resistance (12). Here, ZEB1 is linked to colorectal cancer.