Interestingly, in three of the canine skin HSA samples (DD0158, DD0159, DD0162), we identified an elevated mutation rate and the COSMIC mutational signatures SBS7a and SBS7b (Fig. S3), which have been found predominantly in skin cancers and have a proposed etiology of UV light exposure (Alexandrov et al., 2020). The gene discussed is ALB; the disease is skin cancer.