However, these findings have significant clinical implications, as early detection of HSA by screening blood samples (as is in development at the University of Minnesota; ‘Shine On’ Project, https://vetmed.umn.edu/centers-programs/clinical-investigation-center/current-clinical-trials/early-detection-target-hemangiosarcoma-cells-dogs-shine-project), followed by removal of the spleen or right atrium to prevent an aggressive HSA from growing and metastasizing, is much more likely to be successful (curative) if there is not a high risk of dual primaries forming. This evidence concerns the gene ALB and angiosarcoma.