The mutant SMARCA2 protein causes dysregulation of the expression of neural progenitor genes and neural enhancer reprogramming, and genome‐wide DNA methylation changes are also relevant to NCBRS pathophysiology (Chater‐Diehl et al., 2019; Gao et al., 2019). This evidence concerns the gene SMARCA2 and intellectual disability-sparse hair-brachydactyly syndrome.