NLRP3 and hyperuricemia: Therefore, in this study, by culturing vascular endothelial cells and constructing a hyperuricaemia animal model, we attempted to confirm the molecular mechanism underlying kidney injury; that is, in an HUA environment, HOTAIR induces the activation of the NLRP3 inflammasome and pyroptosis by binding to miR‐22, ultimately promoting endothelial cell injury and causing kidney injury.