To explore novel strategies for the targeted treatment of UA nephropathy, based on the above studies, we injected shHOTAIR lentiviruses, via tail vein, into hyperuricaemia mice and subsequently assessed the inflammation status in kidney tissues The results showed that the protein expression levels of NLRP3 and caspase‐1 in the renal tissues of the treatment group were significantly lower than those in the unrelated lentivirus (scramble) group (Figure 8A). This evidence concerns the gene NLRP3 and hyperuricemia.