To understand the role that IEC IL-10R expression plays in the maintenance of gut barrier integrity in arthritis, we generated chimeric mice that lacked IL-10R on the non-hematopoietic cells but retained expression on cells of the immune system (wild type [WT]→irradiated IL-10R−/− [WT→iIL-10R−/−] mice; Figure 4L). The gene discussed is IL10RA; the disease is Arthritis.