Given that we observed an increase in inflammatory infiltrates in the gut mucosa of arthritic mice and that recirculating pro-arthritogenic cells are implicated in the loss of gut barrier integrity, we next assessed whether morphological changes to the gut in arthritis were accompanied by alterations in the balance of pro- and anti-inflammatory cytokines produced by CD45+ leukocytes in the intestines. Here, PTPRC is linked to Arthritis.