According to this, p62-positive aggregates have been detected in the spinal cord of ALS patients (Mizuno et al., 2006; Sasaki 2011) as well as ALS-related animal models (Sasaki and Iwata, 2007; Kato 2008; Hadano et al., 2010). Here, SQSTM1 is linked to amyotrophic lateral sclerosis.