MFN2 and Charcot-Marie-Tooth disease: Since silencing or depletion of MFN2 leads to decreased MAM formation associated with impaired mitochondrial Ca2+ uptake (Table 3; de Brito and Scorrano 2008; Gbel et al., 2020), perturbations of mitochondrial Ca2+ handling might play a crucial role for motor neuron survival in Charcot-Marie-Tooth disease as well.