SACS and Charlevoix-Saguenay spastic ataxia: Remarkably, other mutations in genes encoding for regulators of DRP1 function have been linked to neurodegenerative disorders: Mutations in SACSIN lead to the development of Spastic Ataxia of Charlevoix Saguenay (ARSACS) due to decreased recruitment of DRP1 to mitochondria (Bradshaw et al., 2016).