Similar to observations made in ALS, increased DRP1 and simultaneously reduced MFN1 levels were measured (Kim et al., 2010), which was further supported by mRNA expression levels showing upregulation of DRP1 and FIS1 towards downregulation of MFN1, MFN2 and OPA1 (Shirendeb et al., 2011). The gene discussed is DNM1L; the disease is amyotrophic lateral sclerosis.