Remarkably, other mutations in genes encoding for regulators of DRP1 function have been linked to neurodegenerative disorders: Mutations in SACSIN lead to the development of Spastic Ataxia of Charlevoix Saguenay (ARSACS) due to decreased recruitment of DRP1 to mitochondria (Bradshaw et al., 2016). Here, SACS is linked to Autosomal recessive spastic ataxia of Charlevoix-Saguenay.