However, preliminary data by Langer and colleagues showed that MCU deletion in Purkinje cells lacking AFG3L2 did not influence neurodegeneration (Patron et al., 2018), suggesting that modifying mitochondrial Ca2+ levels alone is not sufficient to prevent degeneration of Purkinje cells in AFG3L2-related spinocerebellar ataxia. Here, AFG3L2 is linked to cerebellar ataxia.