BDNF and Huntington disease: Protein levels of BDNF were found to be reduced in the striatum of HD patients (Ferrer et al., 2000) as well as HD-related animal models expressing mHTT (Apostol et al., 2008; Gharami et al., 2008), which has been linked to interference of mHTT with synthesis and transport of BDNF (Zuccato et al., 2001; Gauthier et al., 2004).