Disturbed Ca2+ homeostasis has been identified early as a characteristic feature in motor neurons of ALS patients (Siklos et al., 1996) and could be mimicked by various in vitro and in vivo models expressing mutant SOD1 (Carri et al., 1997; Siklos et al., 1998; Damiano et al., 2006), TDP-43 (Stoica et al., 2014) and FUS (Stoica et al., 2016), respectively. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.