This is the case of chromosomal translocations fusing the genes PAX3 and FOXO1 in alveolar rhabdomyosarcoma, which result in the fusion of both RLs and the activation of transcription from PAX3 promoter by enhancers from the FOXO1 RL (Vicente-Garcia et al., 2017). This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.