First proposed by the Dalton Laboratory, FN model allows the researchers to investigate the specific signaling pathways of CAM-DR which involved in cell adhesion associated with FN or β1 integrin activation (Hazlehurst and Dalton, 2001), elucidating the role of two major adhesion molecules, VLA-4 and VLA-5, in hematological malignancies. Here, ITGA5 is linked to hematologic disorder.