Cytoplasmic Notch and phosphorylated Akt (pAkt) correlate with nuclear NFκB in TNBC tumour samples, while mechanistic work in triple negative cell lines demonstrated JAG1-Notch1 (but RBPJκ-independent) stimulation of Akt via mTOR and IκB kinase (IKK) α. Here, AKT1 is linked to neoplasm.