In contrast, expressing an activated form of Notch 1, 3, or 4 seems to be sufficient to drive tumour formation (Smith et al., 1995; Kiaris et al., 2004; Hu et al., 2006; Bouras et al., 2008; Zhang Y. et al., 2016; Onoyama et al., 2020). Here, NOTCH1 is linked to neoplasm.