This leads to predominant degradation of loose collagen fibers and accumulation of highly crosslinked stiff collagen bundles during aging and in photodamaged skin (Quan and Fisher, 2015; Shao et al., 2019) which may contribute to enhanced tumor progression due to tissue stiffening, as has been reported for lysyl oxidase (LOX) (Levental et al., 2009). Here, LOX is linked to neoplasm.