Overall, ID1, ID3, CD44, LIF/LIFr, HLA-G, and HSP70 could be crucial aspecific targets mainly in primary tumor development, whereas exosome mRNAs, miRNAs, lncRNAs, ITGs, and related S100 factors might be important specific targets for blocking tumor progression and recurrence as well as for inhibiting organotropic metastasis locations. This evidence concerns the gene CD44 and neoplasm.