In this first phase, molecular checkpoints playing a major role could be factors able to confer to cells of an initial tumor persistent stemness, self-renewal, pluripotency, survival, and apoptosis inhibition, such as OCT4, NANOG, SOX2, STAT3, CD44, ID, HLA-G, and HSP70 factors (Figure 1). The gene discussed is POU5F1; the disease is neoplasm.