DPYSL2 and malignant colon neoplasm: Dihydropyrimidinase-related protein 2 (DPYSL2), also known as collapsin response mediator protein 2 (CRMP2), belongs to the CRMP family that shares about 50–70% sequence homology, promoting tumor progression in multiple cancer types, including gastric cancer (Yutaka et al., 2013), colon cancer (Goulet et al., 2007), and breast cancer (Tominaga et al., 2019).