Dihydropyrimidinase-related protein 2 (DPYSL2), also known as collapsin response mediator protein 2 (CRMP2), belongs to the CRMP family that shares about 50–70% sequence homology, promoting tumor progression in multiple cancer types, including gastric cancer (Yutaka et al., 2013), colon cancer (Goulet et al., 2007), and breast cancer (Tominaga et al., 2019). Here, DPYSL2 is linked to colonic neoplasm.