STYK1 and cancer: Moreover, overexpressed STYK1 likely stimulates cancer development by sustaining proliferative signaling, leading to abnormal proliferation of cancer cells (Chung et al., 2009; Cao et al., 2016; Chen et al., 2016), enhancing the resistance of tumor cells to programmed cell death (Lai et al., 2019; Shi et al., 2019), promoting the Warburg effect, remodeling cellular energetics in malignant cells (Shi et al., 2017; Zhao et al., 2017), and stimulating angiogenesis and lymphangiogenesis during tumor progression (Liu et al., 2016).