STX2 is also involved in the progression and metastasis of various cancers, such as mammary adenocarcinoma (Bascom et al., 2005), hepatocellular carcinoma (Jia et al., 2011), ovarian cancer (Yew et al., 2013), and colorectal cancer (Wang et al., 2018). This evidence concerns the gene STX2 and hepatocellular carcinoma.