Comprehensive analysis of LSC gene expression signatures was previously performed in 78 AML patients and validated by xenotransplantation, which generated a 17-gene LSC (LSC17) biomarker panel (ZBTB46, SOCS2, SMIM24, NGFRAP1, MMRN1, LAPTM4B, DNMT3B, CPXM1, AKR1C3, CDK6, CD34, ARHGAP22, GPR56, NYNR1N, KIAA0125, EMP1, and DPYSL3). Here, CDK6 is linked to acute myeloid leukemia.