The western blot results showed that PTPN6 overexpression could decrease the p-AKT protein level, while this reduction effect of p-AKT could be further reduced by HNRNPH1 knockdown together in CML cells (Figure 5D), suggesting that PTPN6 may mediate the relationship between the HNRNPH1 and the activation of PI3K/AKT in CML cells. Here, PTPN6 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.