Consistently, HNRNPH1 suppression was found to inhibit the multiplication of CML cells by mainly arresting their cell cycle at G1/G0 phase(K562 44.34% vs. 52.35%, KCL22 43.61% vs. 53.60%)and caused S phase reduction(K562 48.58% vs. 38.86%, KCL22 52.41% vs. 41.9%), suggesting that HNRNPH1 knockdown played an inhibitory effect on cell arrest phase (Figure 2D). The gene discussed is HNRNPH1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.