As expected, the downregulation of circ-MMP11 could repress ANLN expression level in LR breast cancer cells, and miR-153-3p knockdown partially eliminated the suppression effect of circ-MMP11 silencing on ANLN expression, further supporting the circ-MMP11/miR-153-3p/ANLN axis in LR breast cancer cells. The gene discussed is ANLN; the disease is breast cancer.