INS and diabetes mellitus: Diabetes is mainly of two types; type 1 diabetes mellitus, also called insulin-dependent which occurs due to the destruction of insulin-secreting beta cells and lack of insulin secretion most common in children and adolescents, and type 2 diabetes mellitus, which comprises 90% of the diabetic cases, is non-insulin-dependent, caused by impaired sensitivity of target tissue receptors to insulin, and is most commonly associated with obesity [5].