When considering the implications of stress on dendritic cell function, it is important to note that adrenergic stress has been shown to limit cytokine production from dendritic cells after exposure to lipopolysaccharide (Goyarts 2008), impair migration (Maestroni 2000) and chemotaxis (Maestroni 2003) and drive dendritic cells to preferentially promote differentiation of CD4+ T cells into type 17 helper T cells (Th17) rather than the type 1 (Th1) cells (Manni 2011) that are important for anti-tumour immunity. The gene discussed is CD4; the disease is neoplasm.