In other studies evaluating the impact of both acoustic stress and chronic restraint stress on a pancreatic mouse model, it was found that not only did stress increase the number of Tregs in the tumour microenvironment, but there it also reduced the production of both Th1 and Th2 cytokines and increased the production of TGF-β (Partecke 2016). The gene discussed is TGFB1; the disease is neoplasm.