PLOD1 and polycystic ovary syndrome: The granulosa cells from small antral follicles of women with PCOS prematurely switch from FSH to LH responsiveness, as indicated by elevated LH receptor expression and reduced FSH receptor expression compared with unaffected women (Franks & Hardy, 2020; Kanamarlapudi et al., 2016; Owens et al., 2019).