PLOD1 and polycystic ovary syndrome: In contrast to the known HPG alterations induced by relatively high prenatal testosterone characteristic of PCOS, a disorder caused by relatively low prenatal testosterone should centrally involve the following alterations: (1) a lower frequency of GnRH pulses reflected by reduced LH; (2) elevated FSH relative to LH; (3) low ovarian and serum testosterone, and low AMH; (4) faster follicular maturation; and (5) shorter menstrual cycles.