Reduced expression of Myc in Myc heterozygous loss of function mice also leads to reduced TORC1 signalling, increases mouse lifespan, and improves a number of age-related health conditions including osteoporosis, cardiac fibrosis, immunosenescence and several parameters associated with activity and lipid metabolism (Hofmann et al., 2015). The gene discussed is MYC; the disease is osteoporosis.