In contrast, Weber’s study showed that HNF1B and PAX2 mutations caused CKDs with an age of onset between 10 and 23 years (Weber et al., 2006), and autosomal recessive polycystic kidney disease was reported to be the most prevalent etiology in neonatal-onset cystic kidney diseases (Obeidova et al., 2020). Here, PAX2 is linked to cystic kidney disease.