Breast cancer cells promote the expression of SMAD5 in γδT cells through the transfer of the lncRNA, SNHG16, in exosomes, which functions as a ceRNA through miR-16-5p, thereby enhancing the TGF-β1/Smad5 pathway and upregulating CD73 expression (72). This evidence concerns the gene TGFB1 and breast carcinoma.