LIFR and osteosarcoma: In the report by Zhang et al., RNA sequencing and other methods were used to identify differentially expressed miRNAs and lncRNAs in MΦ-CM co-cultured osteosarcoma cells and the corresponding control group, which confirmed that lncRNA LIFR-AS1 was upregulated in MΦ-CM co-cultured osteosarcoma cells (97).