In addition, the SNHG14/miR-5590-3p/ZEB1 positive feedback loop was found to promote the progression and immune escape of DLBCL by regulating the PD-1/PD-L1 checkpoint, suggesting that targeting SNHG14 is a potential method of improving the efficacy of DLBCL immunotherapy (133). This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.