IL22 and arthritic joint disease: Researchers have found that the disease severities of wild-type mice and IL-22-deficient mice are comparable to those of T cell-mediated arthritis,Th17 cells have a strong effect on synovial fibroblasts while targeting Th17 cells and IL-17A but not Th22/IL-22 has been suggested as a focus treatment for T cell-mediated synovial inflammation (97).