observed that the infusion of the antioxidant enzyme catalase, conjugated with a platelet/endothelial cell adhesion molecule-1 (PECAM-1) antibody to nanosized particles, before cardiac arrest, induced a decrease of endothelial dysfunction, lipid peroxidation, alveolar leakage, and edema formation in transplanted pigs (128). Here, PECAM1 is linked to endothelial dysfunction.