IL6 and osteoporosis: As such, the most frequently studied polymorphism, SNP −174C>G, is prevalent in 40% of the general population, associated with varied transcriptional rates of IL-6, and linked to various diseases like Alzheimer’s disease, atherosclerosis, cardiovascular disease, carcinomas, insulin-independent diabetes mellitus, osteoporosis, sepsis, and systemic complications of juvenile chronic arthritis (Fishman et al., 1998; Rauramaa et al., 2000; DeMichele et al., 2003; Jeremic et al., 2014).