IL6 and metabolic syndrome: Interestingly, single-nucleotide polymorphisms (SNPs) in the promoter region of IL-6 (rs1800797) have been linked to increased risk of diabetes and several metabolic syndrome phenotypes (Hamid et al., 2005; Huth et al., 2006; Shen et al., 2008), further supporting a role for IL-6 in skin metabolic processes.