S100A1 and obesity due to melanocortin 4 receptor deficiency: This multigene family has a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation and maintaining immunological homeostasis (Donato et al., 2013; Xia et al., 2017), Elevated expression of various S100 proteins have been associated with psoriasis, impaired wound healing, atopic dermatitis (Xia et al., 2017), tumors, and obesity (Donato et al., 2013).