In total 20 individuals with type 1 diabetes (7 females) were included in the study with a mean ± SD age of 35 ± 11 years, BMI 24.8 ± 2.8 kg/m2, HbA1c 54 ± 7 mmol/mol (7.1 ± 0.6%), diabetes duration 20 ± 11 years, total daily insulin dose 40 ± 14 IU. The gene discussed is INS; the disease is type 1 diabetes mellitus.