GLO1 and neuropathic pain: As the main enzymatic detoxification system of MG (a major precursor of AGEs that have been causally associated with the induction of neuropathic pain (75), the glyoxalase enzyme system, specifically glyoxalase I (GLO1), is responsible for detoxifying them by converting them to D-lactate, thus suppressing the formation of methylglyoxal-derived AGEs and providing primary defense against the reaction of associated glycation (76, 77).