Recently, it was reported that hypothyroidism causes neuroinflammation (Nam et al., 2018) that can be associated with stimulating the IRE1α-TRAF-JNK pathway associated with caspase 12 and Bax-dependent apoptosis (Putcha et al., 2003; Sprenkle et al., 2017) where our result support this finding. This evidence concerns the gene ERN1 and hypothyroidism.