Using the DNMT inhibitor 5-azacytidine (5 AC) as a positive control, it was found that at clinically relevant concentrations (2 μM), DiMC could induce the gene expression of promoter methylated genes such as p15 and CDH-1 in leukemia cells, suggesting a possible DNA hypomethylating effect by DiMC, similar to 5 AC (Hassan et al., 2015). Here, DNMT1 is linked to leukemia.