Compared with those in AR-negative prostate cancer cells (IC50 16.0 μM) or those in normal prostate cells (IC50 27.0 μM), ASC-J9 was found to exhibit a decreased IC50 value in AR-positive prostate cancer cells (IC50 6.5 μM) (Cheng et al., 2018). The gene discussed is AR; the disease is Familial prostate cancer.