ASC-J9 could also inhibit the proliferation and metastasis of prostate cancer by regulating pSTAT3-C-C motif chemokine-2 (CCL2) signal transduction through an AR-dependent pathway via inhibiting the expression of the protein inhibitor of STAT3 (PIAS3) (Lin et al., 2013). The gene discussed is STAT3; the disease is prostate cancer.