Lin et al. further found that ASC-J9 could suppress prostate cancer cell invasion by inducing the sumoylation of STAT3, thereby inhibiting the STAT3 phosphorylation that led to the suppression of the EMT-SNAIL2 signals in both prostate cancer DU145 and PC3 AR-negative cells (Lin et al., 2018). This evidence concerns the gene STAT3 and Familial prostate cancer.