In a study on both hepatitis B-induced HCC cell lines as well as on tumor bearing mice, Rh2 also showed anti-proliferative potential by up-regulation of miR-491, which was shown to target the epidermal growth factor receptor (EGFR) and by reducing its expression to act anti-proliferative (Chen and Qiu, 2015). Here, EGFR is linked to hepatocellular carcinoma.