RASAL2 and familial pancreatic carcinoma: In pancreatic cancer, one study done on different cell lines showed that SFN induced miR-135b-5p expression which, in turn, binds to the 3′UTR region of the Rat sarcoma (RAS) Protein Activator Like 2 (RASAL2) gene, leading to its up-regulation, having an anti-proliferative effect in vitro.