In vitro and in vivo studies on hepatoma cells revealed that luteolin treatment promotes apoptosis and tumor suppression through up-regulation of miR-6809-5p which down-regulates Flotillin 1 by directly binding to the 3′UTR of Flotillin-1 gene mRNA (Yang et al., 2019a). Here, FLOT1 is linked to hepatocellular carcinoma.