Moreover, pleiotrophin (PTN), a growth factor that is highly expressed in several cancers associated with poor prognosis (Jee et al., 2016; Ma et al., 2017), has been found to be modulated by luteolin in colorectal cancer (CRC) cells through the up-regulation of miR-384, which binds to PTN 3′-UTR (Yao et al., 2019). Here, PTN is linked to colorectal cancer.