NLRP3 and Hypertension: Since hypertension is comorbid with migraine in almost 30% of individuals (Bigal et al., 2010), some vascular mechanisms associated with SARS-COV-2 pathophysiology, e.g., participation of nucleotide oligomerisation domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome complex and pericyte dysfunction, may also contribute to the neuro-vasculo-inflammatory mechanisms of migraine (Bolay et al., 2020b).