From analyses of the same three patient breast cancer datasets, we find HIF1A transcripts and its transcriptional targets, CAIX and VEGFA [32], and G3BP1 (but not NRF2) are all significantly higher in breast cancers that exhibit gain of function or amplified KRAS (Fig. 1C, D and Appendix Fig. S2A–C). Here, CA9 is linked to breast cancer.