IHC analysis of de novo tumours derived from KRASG12D-transduced human mammary cells showed increased levels of stress-related translational targets of YB-1, including HIF1α, NRF2, G3BP1 and membranous CAIX (Fig. 6A and Appendix Fig. S9A), compared to matching normal tissue. This evidence concerns the gene NFE2L2 and neoplasm.