This revealed numerous genes whose expression was altered by reducing YB-1 (Appendix Fig. S4B–D), including several related to hypoxia (e.g., PPIF, SLC3A2 and SLC7A1) [38–40] and found to be elevated in breast cancers with increased expression or amplification of YB-1 (Appendix Fig. S4E). The gene discussed is YBX1; the disease is breast cancer.