MICB and neoplasm: To delineate which form or whether both forms of MIC in tumors skews NK cell dysfunction as presented above, we generated mouse and human tumor cell lines that, respectively, express sMIC composed of the ectodomain α1–α3 of the MICA or MICB molecule and the non-sheddable membrane-restricted MIC, mMIC, previously described as MICA.A2 or MICB.A26,32,33.