For the resected pancreatic tumors of Pdx1-Cre;Trp53R172H;Rbf/f mice with a non-fasting blood glucose level of < 80 mg/dL (n = 10), the relative GLP-1R and SSTR2 mRNA expression levels as well as anti-insulin and -glucagon antibody staining of each tumor are as follows: The immunohistochemical analysis of the insulin-positive tumors (n = 6) demonstrated glucagon-negative staining, whereas that of the insulin-negative tumors (n = 6) showed glucagon-positive staining (Fig. 2A), consistent with a previous report22. The gene discussed is INS; the disease is neoplasm.