PDX1 and pancreatic insulinoma: In conclusion, employing [18F]FB(ePEG12)12-exendin-4 PET/CT for the detection of insulinoma yielded favorable sensitivity and specificity in the INS-1 xenograft mouse models and the Pdx1-Cre;Trp53R172H;Rbf/f mice with endogenous insulinoma and glucagonoma.