However, since most of the Pdx1-Cre;Trp53R172H;Rbf/f mice develop insulinoma only at the age of over 180 days and those mice die within 2 weeks after presenting with hypoglycemia as previously reported22, it is challenging to employ a larger number of the mice to complete our comparative protocol between [18F]FB(ePEG12)12-exendin-4 and [68Ga]DOTATOC PET/CT scans. The gene discussed is PDX1; the disease is pancreatic insulinoma.