Recently, we have reported that pancreas duodenum homeobox protein 1 (Pdx1) Cre-dependent pancreas-specific simultaneous deletion of retinoblastoma (Rb) gene with the induction of p53 mutation induces multiple panNENs in islet cells22 and displays endogenous insulinoma and glucagonoma phenotype. This evidence concerns the gene PDX1 and pancreatic insulinoma.