While the exact mechanism underlying the lack of response to 5-FU in GATA6-low tumors remains unclear, GATA6 has been recently shown to play an important role in regulating epithelial-mesenchymal transition and tumor dissemination in pancreatic cancer cells, and GATA6 loss appears to be associated with EGFR pathway activation in PDAC cells, suggesting perhaps a role for treatment response in patients17. This evidence concerns the gene GATA6 and pancreatic neoplasm.