Having found that HSV-1 and CMV infection induces actin cytoskeletal contraction in TM cells, we asked whether the HSV-1 and CMV infection induces the expression of MCP-1 and IL-8 as well as the cytokines and fibrogenic proteins associated with glaucoma in TM cells (Fig. 7). The gene discussed is CCL2; the disease is cytomegalovirus infection.