Elevated level of MCP-1 and IL-8 in the AH of patients with POAG as well as those with hypertensive anterior uveitis, which is characterized by sudden abrupt elevation of IOP (Supplementary Table S1), led us to test a possible role for MCP-1 and IL-8 in TM cell actin cytoskeletal organization and focal adhesions formation. This evidence concerns the gene CCL2 and open-angle glaucoma.