To gain more insights not only into the MCP-1 and IL-8 signaling pathways in the TM cell physiology but also into their pathologic role in POAG and hypertensive anterior uveitis, we first explored the effects of MCP-1 and IL-8 on human TM cells in the context of AH outflow and IOP. The gene discussed is CXCL8; the disease is open-angle glaucoma.